Job Description

Job Title: Senior Research Associate – Drug Metabolism and Pharmacokinetics (DMPK)

Location: Newark, CA

Position Summary:

We are seeking a Senior Research Associate to join our Drug Metabolism and Pharmacokinetics (DMPK) team. This is a critical role within our core drug discovery group, providing a unique opportunity to contribute directly to the development of new drug candidates. The successful candidate will collaborate closely with a highly skilled and cross-functional team, performing in vitro metabolism assays, metabolite identification studies, and LC-MS/MS-based bioanalysis to evaluate the pharmacokinetic properties of novel chemical entities.

This position offers an exciting opportunity to be part of a dynamic, innovative biopharmaceutical environment where your contributions will help advance compounds from concept to clinic.

Key Responsibilities:

• Design and execute in vitro metabolism studies to support DMPK profiling and address key questions in drug discovery.
• Develop and validate analytical methods using LC-MS/MS for the separation, detection, and quantification of small molecules and peptides.
• Perform sample preparation and bioanalysis for both in vitro and in vivo ADME/PK studies.
• Conduct metabolite identification and profiling using liver subcellular fractions and other biological matrices.
• Present scientific findings through presentations and detailed reports to internal teams and stakeholders.
• Contribute to project milestones and influence early-stage drug discovery decisions.
• Stay current with relevant scientific literature and apply findings to internal research efforts.
• Maintain laboratory instruments (especially LC-MS/MS), ensuring they are operational and accessible to the team.
• Keep accurate and thorough experimental records in accordance with scientific and regulatory standards.
• Perform additional duties and contribute to cross-functional initiatives as needed.

Qualifications & Experience:

• Bachelor’s degree in Biological Sciences, Chemistry, or a related field with 5+ years of hands-on DMPK lab experience; OR
• Master’s degree in a relevant field with 2+ years of relevant experience.
• Proven experience with LC-MS/MS-based sample analysis, particularly in metabolic stability, CYP inhibition, and metabolite ID studies.
• Hands-on experience with sample preparation and bioanalysis in support of preclinical ADME/PK studies.
• Strong preference for candidates with expertise in Sciex instrumentation and method troubleshooting.
• Demonstrated ability to independently plan, execute, and troubleshoot complex experiments.
• Excellent verbal and written communication skills with a collaborative and adaptable approach.
• Self-motivated, detail-oriented, and enthusiastic about working in a fast-paced and team-driven environment.

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